Sweet Chemistry
3% Matrikynes® Peptides in Every Formula
Where regenerative medicine meets uncompromising cosmetic science to create evidence-based skincare worth the hype.
Upgrade From Singular Peptides To 315 ECM-Extracted Peptides
Conventional peptide serums deliver a single synthetic signal. Matrikynes® deliver 315+ bioactive peptides pulled from the living extracellular matrix, the full set of cues your skin releases when it repairs itself. Why hand your skin one page of instructions when it can have the entire manual?
Awards
2026 Best Biotech-Driven Skin Regeneration2026 Editor's Choice for Spring Beauty Staples2026 Best Regenerative Serum2026 Best Barrier Repairing Serum2025 Brightest Start-Ups in Beauty2024 Best Breakthrough Technology FinalistWinner Best Firming Serum 20242023 & 2024 Best Serum for Damaged Skin2023 Breakthrough Regenerative Medicine Ingredient
Formulated to be used individually or mixed together for customizable emollience, hydration, and activity.
Everyone’s skin has different needs, which is why all four of our products deliver similar benefits in different textures and finishes. Use individually, or layer from lightest to richest for amplified results.
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03
Barrier Repairing Hydra-Serum
$158.00
Perfect on its own for oily skin or in hot and humid climates, or as a lightweight underlayer beneath our creams for any skin type.
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02
Elasticity Reinforcing Hydra-Cream
$148.00
For combo to dry skin or for humid days where you want less emollience, quick absorption and dry down.
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02
Elasticity Reinforcing Lipid-Cream
$148.00
For easily dehydrated skin or for drier days where you want more glow and emollience.
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03
Barrier Repairing Oil-Serum
$170.00
Use alone as a treatment facial oil for dry skin, or infuse into creams for added repair and emollience, or as an overnight treatment.
Every Few Decades, A New Innovation Disrupts The Skincare Industry
0.01%
Marketing levels
This means your favorite product may only contain around 0.01% of any given active ingredient. This percentage is all it takes for an ingredient to appear in the ingredients list and be marketed to you as a “hero” ingredient.
Less Marketing, More Space for Actives
We love telling the stories behind our formulas. Just not “ingredient stories”. Many dermatological and botanical actives you will find in conventional cosmetic products are formulated at marketing levels, sometimes referred to as “ingredient stories”.
We use a modern, transparent approach to formulating: All of our dermatological active ingredients are included at functional levels, with our botanical actives at a minimum of 1% each. In our ingredient list, we’re also always transparent about our 1% line.
0.01%No marketing levels
03 Barrier Repairing Hydra-Serum
+ All actives at functional use levels in a 54% water emulsion
- 3%Matrikynes® regenerative upcycled bovine bone Peptides
- 5%Industry peptide
- 5%Niacinamide
- 3%Ceramides (NP, AP)
- 2%Seaweed Glycan
- 1%Cholesterol & 1% amino acid blend
02 Elasticity Reinforcing Hydra-Cream
Formulated to deliver all actives at optimal functional levels within a 54% water & 6% emulsifier emulsion
- 3%Matrikynes® regenerative upcycled bovine bone peptides
- 5%industry peptides
- 3%Ceramide, phytosphingosine, cholesterol blend
- 2%THD ascorbate
- 1%Amino acid blend
02 Elasticity Reinforcing Lipid-Cream
For our Elasticity Reinforcing Lipid-Cream, this means we formulate using 30% less water with antioxidants and actives making up 45% of our emulsion.
- 3%Matrikynes regenerative ECM polypeptides
- 3%Ceramide, Phytosphingosine, Cholesterol Blend
- 2%THD Ascorbate
- 1%Amino Acid Blend
- Formulated to deliver all actives at optimal functional levels within a 44% water & 10% emulsifier emulsion
03 Barrier Repairing Oil-Serum
For our Barrier Repairing Oil-Serum, it means you’re getting a waterless serum formulated with powerful actives and efficacious botanicals each at a minimum of 6%.
- 7%THD ascorbate
- 7%Squalane
- 3%Matrikynes® Matrix-Derived Peptides
- 3%ceramides
- 2%omega 3s
- 1%cholesterol
- 0.5%Coenzyme Q10
- 0.2%phytosphingosine
1% line
Save 10-15%
Max Repair Systems
For Advanced Regenerative Daily Performance. Subscribe to unlock additional savings.
Sweet Chemistry was formulated to be used as a system –each product layers actives that work synergistically for maximum benefits.
Shop now-
Lightweight
Hydra-Cream + Hydra-Serum Max Repair System Duo
$275.00
For those with combo to dry skin who prefer a plumping water-based serum and a satin-finish treatment cream.
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Mid-Weight
Hydra-Cream + Oil-Serum Max Repair System Duo
$286.00
For those with dry skin who love a satin finish during the day but want the flexibility to add active emollience at any moment or overnight.
4.8 from 46 Reviews
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Rich
Lipid-Cream + Hydra-Serum Max Repair System Duo
$275.00
For those with dry skin who prefer a plumping water-based serum underneath an emollient treatment cream with a radiant finish.
4.9 from 49 Reviews
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Extra Rich
Lipid-Cream + Oil-Serum Max Repair System Duo
$286.00
For those with dry, easily dehydrated skin who love an emollient treatment cream and active-filled facial oil.
Complete Max Repair System
$530.00
For those who want a fully customizable routine, ideal for frequent travelers and shifting climates.
Independent clinical studies showed statistically significant improvements in barrier function, barrier repair, density, hydration, hyperpigmentation, and global fine lines and wrinkles.
A modular system of emolliency and actives
Lipid-Cream + Hydra-Serum
For maximum skin repair of dry skin, add a small pump of the Barrier Repairing Hydra-Serum to the Elasticity Reinforcing Lipid-Cream in the palms of the hands, mix and apply to the face, neck, décolleté, and earlobes.
Cold or dry climates
Add more Hydra-Serum to the Lipid-Cream in extra cold or dry climates or when it has been exposed to environmental aggressors.
Normal or combination skin
For normal or combination skin, feel free to use the Hydra-Serum or Lipid-Cream alone during the day and add the other at night for more emollience.
Hydra-Serum, day and night
Apply to clean skin, day and/or night – face, neck, décolleté, and earlobes. For intensified activity, infuse or layer the serum with our Elasticity Reinforcing Hydra-Cream.
Results designed to compound.
89.3%
agree their skin looks more resilient
85.7%
saw reduced lines & wrinkles
91%
saw improved skin texture
90%
agree their skin looks healthier
89.3%
saw smoother skin
85.7%
agree their skin looks revitalized
Results That Are Never Retouched
Representative VISIA CR photography. None of the below photographs were altered, edited, or retouched.
Let’s Get Clinical
Independent clinical studies show that Matrikynes® deliver statistically significant improvements for multiple skin types and tones: In a clinical study of 56 women of varying race and ethnicities, Matrikynes® showed statistically significant improvements in skin barrier function, skin barrier repair, skin density, skin hydration, hyperpigmentation, and global fine lines and wrinkles.
12%
Improve skin barrier repair within 1 hour
Skin barrier repair improves 12% faster and 61% better within 1 hour, rapidly supporting skin’s restorative and refortifying abilities.
Within 1 hour
8.3%
Increase skin density (collagen)
Skin density increases by 8.3% within 4 weeks, signaling skin to restore collagen and strengthen itself for a revitalized, youthful appearance.
Within 4 weeks
3.7%
Visibly reduces global fine lines & wrinkles
Fine lines and deep wrinkles are visibly reduced by 3.7% and skin looks noticeably smoother in only 4 weeks.
In only 4 weeks
8.4%
Increase skin hydration
Essential skin hydration increases significantly by 8.4% within 4 weeks and continues to build with regular use.
Within 4 weeks
5.8%
Improve skin barrier function
Skin barrier function improves dramatically by 5.8% in just 4 weeks, enabling skin to ‘act efficiently’ like younger, healthy skin.
In just 4 weeks
3.6%
Improve the appearance of hyperpigmentation & age spots
Hyperpigmentation/age spots are reduced by 3.6% within 4 weeks for more even skin tone and brighter complexion.
Within 4 weeks
An 8-week clinical study found a 15% increase in skin density, tracked by ultrasound and not just a customer survey. Improvements are seen within 4-6 weeks of consistent use.
See the scienceAs seen on Wall Street Journal
"The Best Documentation for the Science Behind Their Products.”
Out of 136 brands investigated, Sweet Chemistry was noted as a top skincare brand for scientific credibility and transparency.
Bioengineering Is at the Heart, Lungs & Skin of What We Do
Aside from being our award-winning formulas’ defining ingredient, Matrikynes® are used in clinical applications in regenerative medicine: They were born from innovative research in organ tissue repair by Dr. John O’Neill, originally from Columbia University's Laboratory for Stem Cells and Tissue Engineering, and his team at our parent company Xylyx Bio.
From Research to Routine
Sweet Chemistry® was founded in collaboration with Xylyx Bio, a biomedical technology company focused on tissue engineering and organ rehabilitation. Together with Xylyx as our R&D liaison and parent company, we are passionate about creating highly effective products powered by research that saves lives.
8 Years of Research & Over $8 Million In NIH Government Funding
Originally used in clinical applications to repair lung tissue, Matrikynes® are a proprietary combination of potent bioactive natural matrikine signal peptides. Matrikine signal peptides have been shown to improve the structure, function, and appearance of skin.
- Increased Cellular Renewal By 336%
- Increased Regenerative Gene Expression By 316%
The Origins of Matrikynes®
These matrikine signal peptides are derived from extracellular matrix (ECM), the essential, life-sustaining substance that surrounds every cell in your body. ECM gives cells the ability to organize and communicate which signals your skin to regenerate and repair.
What makes bone the source of choice for our polypeptides is that it is a tissue with natural regenerative properties and an unparalleled reparative capacity. Our Matrikynes® Regenerative Matrix-Derived Polypeptides are derived from ethically sourced, upcycled bovine bones from the food industry that would otherwise go to waste.
“Without ECM, Life Could Not Exist. Plants Would Not Grow Tall, and Animals Could neither Swim, nor Walk, nor Fly.”
A Cosmetic Chemist and a Biomedical Engineer Walk into a Lab
Innovation born from decades of research in tissue regeneration and cosmetic science
Dr. John O’Neill, CSO & Co-Founder
Biomedical Engineer & Organ Regeneration Pioneer
Dr. O’Neill, originally of Columbia University’s Laboratory for Stem Cells and Tissue Engineering, is an expert in the field of regenerative medicine with notable success for his pioneering work in organ repair for transplant and the invention of peptide biomaterials from natural extracellular matrix that support tissue regeneration.
Alec Batis, Co-CEO & Co-Founder
Industry Innovator & Former Corporate Chemist
Alec Batis is an accomplished chemist and marketer who has spent the past 35 years working with companies such as Pfizer, Shiseido, NARS, Victoria’s Secret Beauty & L’Oréal Group/Redken/Kiehl’s. He currently serves on the Global Cosmetic Industry Advisory Board.
He has a vision for skin health and is now sharing his first-of-their-kind formulas that he’s used for over 35 years. Ones that optimize activity by rethinking emulsion processes, utilizing functional levels of actives instead of marketing levels, reducing microbiome-damaging pesticides, and innovating packaging and preservation techniques.
Why We Call Our Chemistry, Sweet...
Our name embodies our philosophy: science as warm and life-affirming, not cold or intimidating. It's about seeking knowledge in a universe of the unknown. It's hard but necessary, frequently failing but never giving up. And every success is sweet.
The word "chemistry" also refers to the connection between people which is in itself a thing of beauty. And similarly to science, we know that the transformative arts also have the power to uplift and unite.
This isn't a generic algorithm
Skincare Quiz: 30 Seconds to Max Repair
Your skin has its own needs. Alec Batis, co-founder & chemist, formulated every product to work on its own or as a Max Repair System for compounding results. Answer 5 quick questions and get matched to your custom max repair routine with confidence.
Backed by 36 Years of Formulation Experience.
40%
Organically Farmed
Apart from that, organically-farmed ingredients are 40% more expensive than conventionally-grown botanicals.
Let’s Talk Product Prices
We understand that our products can seem high at first. Once we gain enough traction through higher production quantities, we are hoping to lower them by continuing to follow a dynamic pricing model. This way, we aim to become accessible to more people.
How We Price Our Products
Instead of using market-driven retail prices, we simply add our operating margin on top of our cost of goods to come up with each product’s retail price.
The Reason Behind Our Prices
So how come our products are more expensive than the average serum and moisturizer on the market? Allow us to explain with the help of our brand values:
And while our products have a significantly higher cost of goods, we believe the results you will see in your skin are worth it
For the first time ever
Subscriptions Are Now Available For Max Repair System Duos 20% Off Every Order
Introducing our Max Repair System Subscription Program. An easier way to maintain consistency so that your results compound over time.
Subscribe & save20%
Subscribe & Save 20% On Every Order
Just click on your preferred system according to skin type—once on the product page, choose the 'Subscribe' option when checking out and we'll ensure your Max Repair System is delivered regularly at your preferred interval.
15%
Subscribe & Save 15% On Every Order
Not ready for a full system? No problem. Subscribe to any single product to save 15% and never run out of your skincare essentials.
- Skip, pause or cancel anytime
- Free shipping on every order
- Free returns within 45 days, no questions asked
- Delivered every 4 weeks, 6 weeks, 8 weeks, 10 weeks or 12 weeks
87%
Less plastic
Our packaging uses 87% less plastic and protects our actives so you get the performance you expect.
The World’s 1st Airless Glass Packaging
Most airless bottles used for skincare are made from plastic. While the beauty industry is making an effort to use alternative materials such as glass, most glass used for beauty products tends to be heavier in weight than plastic packaging and therefore usually not the more eco-friendly choice.
Meet the world’s first ultra-light glass airless bottle: Aside from the small plastic pump/overcap, our packaging is crafted from lightweight Italian glass, so light in fact, some of our customers have even mistaken it for plastic. We also designed our bottle so you are able to dispense every last drop of product.
Despite being ultra-light, our bottle is made of carefully crafted low-weight Italian glass. It uses an average of 87% less plastic by mass than plastic airless packaging and is free of leachables like BPA and PFAS.
All ingredients inside our airless glass pump bottle are protected from oxidation and minimally exposed to air thanks to a narrow stem and small plastic overcap that make sure all actives remain stable across uses.
The Noble Yarn Edit
The pieces that carry, protect, and wrap around your routine. From travel to nightstand. Spun from the highest quality noble yarn, made for the most prestigious brands in the world.
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Cashmere Blend Ritual Headband
$42.00
A soft, effortless headband for every part of your routine.
Material: Premium 63% Merino Wool, 27% Cashmere, 9%Nylon, 1% Spandex
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Cashmere Blend Reset Eyemask
$72.00
Silk interior for gentle contact against skin and lashes.
Material: Premium 70% merino wool, 30% cashmere exterior with 100% silk lined interior and silk scrunchie back
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The Merino Essentials Bag
From $60.00
A soft, flexible travel essential made for wherever you’re headed next.
Medium Dimensions: 8.7" × 3.5" × 4.5". Large Dimensions: 9.8" × 4.7" × 5.5"
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Merino Bottle Sleeve
$12.00
Protects the airless fine glass bottle from any accidental drops, keeping your serums and creams safe and cozy.
What Our Community Thinks
Sweet Chemistry Reparative Oil combined with Elasticity Reinforcing Cream has returned my skin to a more youthful appearance! Friends say I look glowing and I’m turning 65 this year!
10/10 would recommend! It's worth every penny! Love that it's cruelty-free, fragrance-free, and packed with antioxidants. My combination skin is finally balanced and glowing! It's reduced my pores, evened out my tone, and given me a radiant complexion. A game-changer for anyone seeking effective, sustainable skincare.
If your skin craves moisture like mine does this product is definitely worth giving a shot. The Elasticity Reinforcing Cream is a lightweight moisturizer that seeps into your skin giving it much needed regeneration and hydration without leaving a greasy residue which is perfect for wearing underneath your makeup.
Every time I use this product, I am amazed at how effective it is in making my skin look so healthy and supple. The product definitely gives my complexion a youthful bounce.
Let me tell you, it did not disappoint. My skin looks and feels hydrated and bouncy. A big win in my book.
1%
Of Sales Donated
to underfunded science and art education programs
The Beauty of Purpose
As a beauty brand, we’re committed to challenging rigid ideals and creating a space where everyone, especially young people, can confidently express who they are—beyond looks. That’s why we donate 1% of sales to support the next generation of scientists and artists, and spotlight our parent company Xylyx’s groundbreaking research in organ rehabilitation—because beauty goes beyond skin deep.
iResearch
The iResearch Institute is a study program for high school students without access to advanced science education - founded by the godmother of science research, Dr. Serena McCalla.
YoungArts
YoungArts identifies exceptional young artists, amplifies their potential, and invests in their lifelong creative freedom. It envisions a world that embraces artists as vital to our humanity.
Xylyx Bio
Our parent company, Xylyx Bio, is a biomedical technology leader in tissue engineering and organ rehabilitation, dedicated to eliminating the organ donor waitlist.
We Were Told Not to be “Too Transparent” … ...but We’d Rather Stay Committed to Our Pledges.
There Is No Such Thing as "Cruelty-Free" Considering the beauty industry’s history, no product on the market can be truly “cruelty-free”. This is because most ingredients used in today’s formulas were once tested on animals, and no brand should hide that fact behind "cruelty-free" claims.
We use already-available safety data to avoid testing our ingredients or formulas on animals. Before adding ingredients to our formulas, we carefully consider their social, ethical & environmental impact.
Matrikynes® vs Growth Factors
Matrikynes® are different from growth factors and exosomes, even though they all fall under the broad umbrella of ‘cell-signaling factors’. Matrikynes® are small, naturally-occurring peptides derived from the extracellular matrix, which is your skin’s native structural network. Unlike growth factors or exosomes, which can stimulate many cellular pathways (some of which are still being studied), Matrikynes® are highly specific and work primarily to support skin repair, renewal, and resilience.
Deliveries
At Sweet Chemistry, quality and customer satisfaction are our top priorities. We service and ship e-commerce orders from our facility in New York City with the goal of processing orders within 24 hours of receipt. All e-commerce orders in the U.S. ship complimentary via tracked carrier and typically arrive between the hours of 9AM and 8PM. We are not able to deliver to P.O. Box numbers, BFPO or freight forwarding addresses.
Subscriptions
Subscription members receive an exclusive 15- 20% discount on all products on every order. Navigate to the product page of the item you want a subscription to, where you will see two purchasing options. Select the 'Subscribe & Save' option. and choose the replenishment frequency in the drop-down menu. You can conveniently update or cancel your subscription by signing into your Sweet Chemistry account.
Please note: We are unable to update or cancel a subscription renewal order once it has been processed and shipped. Any changes or cancellations must be completed at least 3 business days prior to the scheduled renewal date.
Order Tracking
Once your order is placed you will receive an order confirmation e-mail followed by a shipping notification with a link to track your package delivery status.
Sales Taxes
We are required by law to collect sales tax on all e-commerce orders being shipped to New York, the state in which our company is located. Sales tax is applied to the total purchase and will be displayed through the checkout process and on the receipt.
Sweet Chemistry
Bioactive Skincare Powered by Science
Your skin is constantly assaulted from photodamage, oxidation, and aging—our advanced skincare touts Matrikynes®, patent-pending peptides designed for organ repair. Backed by 10 years of in-house R&D, our modular system delivers proven ingredients at functional levels for optimized results.
Now Shipping Worldwide Complimentary Shipping On Domestic Orders.
- 15% off your first order
- Free 45-day returns, no questions asked
- Flexible payment options at checkout